	   SnapGene      ÚGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCGCTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGCGGTAATACGGTTATCCACAGAATCAGGGGATAACGCAGGAAAGAACATGTGAGCAAAAGGCCAGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAGGCTCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGTGGCGAAACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGGGAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTCGGTGTAGGTCGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCCGACCGCTGCGCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACTTATCGCCACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAGCGAGGTATGTAGGCGGTGCTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACTAGAAGAACAGTATTTGGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCTTGATCCGGCAAACAAACCACCGCTGGTAGCGGTGGTTTTTTTGTTTGCAAGCAGCAGATTACGCGCAGAAAAAAAGGATCTCAAGAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCACGTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTTAAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCTGACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTCGTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGGCTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCTCCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGTCCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAGTAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCATCGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGATCAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGGTCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATGGCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGACTGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGCTCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAAGTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGCTGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATCTTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGCAAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTTCAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTGAATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAGTGCCACCTGACGCGCCCTGTAGCGGCGCATTAAGCGCGGCGGGTGTGGTGGTTACGCGCAGCGTGACCGCTACACTTGCCAGCGCCCTAGCGCCCGCTCCTTTCGCTTTCTTCCCTTCCTTTCTCGCCACGTTCGCCGGCTTTCCCCGTCAAGCTCTAAATCGGGGGCTCCCTTTAGGGTTCCGATTTAGTGCTTTACGGCACCTCGACCCCAAAAAACTTGATTAGGGTGATGGTTCACGTAGTGGGCCATCGCCCTGATAGACGGTTTTTCGCCCTTTGACGTTGGAGTCCACGTTCTTTAATAGTGGACTCTTGTTCCAAACTGGAACAACACTCAACCCTATCTCGGTCTATTCTTTTGATTTATAAGGGATTTTGCCGATTTCGGCCTATTGGTTAAAAAAATGAGCTGATTTAACAAAAATTTAACGCGAATTTTAACAAAATATTAACGCTTACAATTTCCATTCGCCATTCAGGCTGCGCAACTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAAAGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTCACGACGTTGTAAAACGACGGCCAGTGAGCGCGCGTAATACGACTCACTATAGGGCGAATTGGGTACAAGCTTGGATTTATTTTGTTATGTTATATGTATTATATGTCAGACATAAAGAAAAGGAACACATCAAATGTGATAACAAAGACTAAACAAGTAATTTTATTACACCAAAACGACAAAACAGTAGGCAGAACAAACAACGCATAGCCAAACATTGACGAATTGGATACCCTGCCGATTGTCAGACACTTTTGTTGATCAGTTTCTTGCGAATGGTCTCGTCCAGCGGTGGAATCGCCTCGCGGGGAATCAGAAAAGTGGACAGATTGAACAGATCCAGAAACACCTTGTACCGATCACTGAAACCAAAAAAAAACAAAGGGAGAACAGTTTGAGTTCATTGATCCCCGATATAATCACATCTGCGATGATCACCTGAGAGTGGAGCGCAGATATTGATATCCAGACGAGCCACCAGTGCCCAACTGTTGGGATCCAATCATGCGTTGCACCATGATCACGTGATTGTCTGCGGCGGGAATAGAAAGTATTTGGTTAGGAAAACCAGTCTTAAACATAAGATATATTTATAAAAGAGTATCAAAGAATGCAATACTTACATCTCCACTTGGTTATTAACGAGTCGATGTCCATGAGCAGGGTGAGCAACTGGTGTGGTTGGCTGAACCTGGGTTCATCCCTATAGAAGGTGATCATGATGGCTCCCTGAAGGGCACGATGGCTAAACCGGCGATCCCCACGACGCACCAGTGCATCGTGCACTGCCGGATCAAAGATGGAGCGATACACCTCGCGTCGCTTCTCAATGTCCATGAGGCGGTAGTTTTTCGCCTTCTCCACGGGCTCCTCCATGGCGCTCTGTACCTGCGCCTCCAGGAATCGATCGACGCTCTCCTGAAACTTGGCCCAGAAGTTGAAGCCACTCTCCTCCAGTCCGGGCGTCCTCTCCAGCCATCGCTGCACTAGCTCCAGTAGCGAGGGATCTTTCTCCGAGTTGCGAATCGAGTTCCGCGCCTCCTCGTCGCTAAAGACATCCGAGTACTTCTGGTTGTATCTCACCCGCTGCTCTGTCAGAACTCCCAGCTTGTTCTCGATCAAACGGAACTGCAGCGACTGAAAACCAGATGCGGGTGCCAGGTACTTGCGGAAGTCCATGAAGTCTAGCGGGGTCATGGTCTCCAGAATGGGCACTTGGTCCACCAGGAGCTGTACAAAGGAAGTTATAAACGGATTTTGGTAAGAGATTCAGAAAGCACTCACTTTTAGAATCAGAACCACTCGGTTCAGTCGCTTGACAATCTCCAGCGTCTTGGTTTCATCGATGACCTCTGCATCCAACATGTCTCGTATGGAGTCGAACTCAAAGATGATCTGCTTGAACCAAAGCTCGTAGGCTGTGGCGAAGGTACTTAAATGCCATTGAGTGTTGTCATCAAAGTTGTAAACCTACTCACCCTGGTGCGTGATGATGAACAGATGCTCATCGTGCACGGGTCGCTTGTCCTCCTCGGACAGCATACACTGGGCATCCAGCAGTTTGTCCAGCATCAGATACTCTCCATAGATTTTGCCCACTTCCGTGGTTAATGGCACCGCCGAATCATCGTGATCGTTTCTGTATGGGTTTGAATTGAATCGCAGAACTGAAGATCGATTGGCATTCCTGGACAGCACGTGCTGGTGCTCACCCGTTTCCTGCATAGGGACAGCTCATGGTGCACAGCTCAGATCAGATCGTGACTCCTCGAGCGGCGGATGCTGGCGAACTGATCTCCGCCAGCGGACCGGAGATGAGACCCCAGCGAACCGATAACAGAGCGAGAGAGCTCCAGTTCCGACTGATTGCACAGTCGGTGATCTGGGCGATGGGCACTGCCAGATAGGCTGGGAATTATCAATCACTTGAGGTGAAAGTGCGGCGCACACAAATCCAAGCTTGATATCATCGATCTCGAGGCTGCATCCAACGCGTTGGGAGCTCTCCGGATCAATTCGGCTTCAGGTACCGTCGACGATGTAGGTCACGGTCTCGAAGCCGCGGTGCGGGTGCCAGGGCGTGCCCTTGGGCTCCCCGGGCGCGTACTCCACCTCACCCATCTGGTCCATCATGATGAACGGGTCGAGGTGGCGGTAGTTGATCCCGGCGAACGCGCGGCGCACCGGGAAGCCCTCGCCCTCGAAACCGCTGGGCGCGGTGGTCACGGTGAGCACGGGACGTGCGACGGCGTCGGCTGGTGCGGATACGCGGGGCAGCGTCAGCGGGTTCTCGACGGTCACGGCGGGCATGTCGACAAGCCGAATTGATCCACTAGAAGGCCTAATTCGGTACACTAGTTGGCCACGTAATAAGTGTGCGTTGAATTTATTCGCAAAAACATTGCATATTTTCGGCAAAGTAAAATTTTGTTGCATACCTTATCAAAAAATAAGTGCTGCATACTTTTTAGAGAAACCAAATAATTTTTTATTGCATACCCGTTTTTAATAAAATACATTGCATACCCTCTTTTAATAAAAAATATTGCATACTTTGACGAAACAAATTTTCGTTGCATACCCAATAAAAGATTATTATATTGCATACCCGTTTTTAATAAAATACATTGCATACCCTCTTTTAATAAAGAATATTGCATACGTTGACGAAACAAATTTTCGTTGCATACCCAATAAAAGATTATTATATTGCATACCTTTTCTTGCCATACCATTTAGCCGATCAATTGAGATCTGAATTCTTTTTTGCTCACCTGTGATTGCTCCTACTCAAATACAAAAACATCAAATTTTCTGTCAATAAAGCATATTTATTTATATTTATTTTACAGGAAAGAATTCCTTTTAAAGTGTATTTTAACCTATAATGAAAAACGATTAAAAAAAATACATAAAATAATTCGAAAATTTTTGAATAGCCCAGGTTGATAAAAATTCATTTCATACGTTTTATAACTTATGCCCCTAAGTATTTTTTGACCATAGTGTTTCAATTCTACATTAATTTTACAGAGTAGAATGAAACGCCACCTACTCAGCCAAGAGGCGAAAAGGTTAGCTCGCCAAGCAGAGAGGGCGCCAGTGCTCACTACTTTTTATAATTCTCAACTTCTTTTTCCAGACTCAGTTCGTATATATAGACCTATTTTCAATTTAACGTCGGGGCTTTGAGTGTGTGTAGACATCAAGCATCGGTGGTTCAGTGGTAGAATGCTCGCCTGCCACGCGGGCGGCCCGGGTTCGATTCCCGGCCGATGCAGGGTCTTCGTTTTAGAGCTAGAAATAGCAAGTTAAAATAAGGCTAGTCCGTTATCAACTTGAAAAAGTGGCACCGAGTCGGTGCTAACAAAGCACCAGTGGTCTAGTGGTAGAATAGTACCCTGCCACGGTACAGACCCGGGTTCGATTCCCGGCTGGTGCAGAAGACCTGTTTTAGAGCTAGAAATAGCAAGTTAAAATAAGGCTAGTCCGTTATCAACTTGAAAAAGTGGCACCGAGTCGGTGCTTTTTTGCCTACCTGGAGCCTGAGAGTTGTTCAATAAAATAAAAATGTTTCGTTTTTTTGCTTTCGCCAGTATTTATTATTTTTCATCAATATGTATTCAATTTGGTATGTATTTAGTAATTGTAATATATAGACAATGGTTTTCCGTTGACGTACATACATCTGACGTGTGTTTATTTAGACATAATAGTTATGTTTTCACATCTTTTTAATGTTCGCTTAATGCGTATGCATTCTAGACAATTGTGCTCGGCAACAGTATATTTGTGGTGTGCCAACCAACAACCTGCAGGAGCTCCAGCTTTTGTTCCCTTTAGTGAGGGTTAATTGCGCGCTTGGCGTAATCATGGTCATAGCTGTTTCCTGTGTGAAATTGTTATCCGCTCACAATTCCACACAACATACGAGCCGGAAGCATAAAGTGTAAAGCCTGGGGTGCCTAATGAGTGAGCTAACTCACATTAATTGCGTTGCGCTCACTGCCCGCTTTCCAGTCGGGAAACCTGTCGTGCCAGCTGCATTAATGAATCGGCCAACGCGCGGGGAGAGGCGGTTT  9µ                           "            *                           $                  (                        $               %                        %         "         !               .      '                        $         !      !                              ,   \   $   &      ,   %         !                        &      $   #      0         )                                                               +                                  %                        (                +                     &      $      $   )         .   O   )                              #             
            +                                       "            %         %       #      *            #      !                                             '         '      '               1                                          s 'cu34²	³	ŒÅU]Ê t qL»&ó	€	´	fÔÑ¥]´p¢�Ë (Í;v¹AsÎ	Ù	#
}œg�ÒTûCÓ ·Bí^  ¹ |dû5†…	’	
ÅG§ òCJŠÆçýV— ¯g¥±Eùµ»ÐÌ  ¤ *r§8x¼UÜô×�	`
jKx¾^q
Gž u W0Mh'tN	µ	/
Ê
ÕýÒËØ¿½ Å)ä€¦ô£" û ¡J`ÚÝÎº¿t�		~‰®h°Ž±;qöüJ�™¸uS¨¹_ E Z ”ê)?†³ÔÏ	$
1oÒ{ÐP€"7 b Ý)^�<wÂBzš	Ú	`Ž�ÿ,UÔfèx¡C7îÔ 0 §)T°�kîü
Ž”¨Óâè2D“Þ¸	*  > W ½ þ zG9eü¨¶†	«	Â	
ÿ×.S¨uÕßD|M]h‹®äàþ˜þÑ ÂÏù£àW¤
Æ¡ó3wKÇèTû�¨ 8 Ë ºn!V6q	’ºÎHoY¢É´WßO� ” Ÿ ± c-}ˆ‡	“	ù	†	›­¿ ù =Í,Ïo HÞûëÏ ZFö„hŸ×úÿ�¤ùÂÍ ùS®¦Ä<à°s¡=jÞêFŒ¿]£Äi A Œ Ü 9�ÑJ)	 
¦¾x�	²Ñ¶œÅg¼ÑBm +s[x—‰yˆ½~Ý.‚	«ÂŒ’y‚¿xlîrYH$ € ¨ÿ=Vhe‹®	[
"=S	Zßt��æS0RÈãËóm•Ÿ m øõZC	
Å
ø
Gkåœð<Z__ø5@«\Ä„&º „ ¥ Æ{9>Øa
¨
2j–0LöK`½gâ
?` Ì�w¶	”o·Ëb'T·ºÂÙüGÜ<± v X>(O“p
Ë
ƒ­³.U‘¾j 1ôN\]Hnû		.	Å	0
Ö
.õÌÙs/rÁ7¦H( ½iuÞ3Esu†ª‰	ê
7L|—Öí±ÚþpÓCWFo¾Ãç>šÀWýœ¦ Ù ì .™—©é	ö	Â
»ãtÙ¤«ÛãPBQ 	µÿS
˜
Þ
*å�§ðh1a› " þÙÆ
y
VÉ+, GØHÑ_*õ�?=\ ü x^aÛ6‹ÿ½À„Ã
'£Œs*K‘v~ù ›· Š Ë×ÞÏÏuþ	n
ó¯µDÇ<rš¿ék ¢¾	�ý»ŠŽ,¤_acTVºR$ 6ÀK4RIž�NŽ	¹	Çìói±Ì‰�²x÷ý§¹.|T©¢¼`© ‘¤D´ÕÊ£�¡
2ÊlßQÁe�# [ ª ë*¨Æ�È“Ð	ï	
ƒ
ÓŸ%Z!'T  F •@€‡žÿ^F
?AP”6ò
�¯ â%
G[p·|Ñ+8E% · °÷µçêOw…�
¬}	Ë	ì	ç
Ñã��à�œ±T2dóM`gÆ?‚ c žG¹Õ>_‘ž=Ã	:
?
aÂ-éÕèwŠjï$ À  ÞæŒÜÇ›Û	ï
o5þJV™¬~¦¿aÛà8XoÕ 4 B�«ÏUìÍ*\ŒxC{¸Íužì= &Õ2y¢DÉ‚ß 1 ¨lûHÔ8ÖE±íR¥š¦ õ Uz¼î$ä	O
Ú
,�“ã”Íßç
 ô*±ãªCïý
ù!…•<é¹ _ûŽl²r&£«|©Û3ä†% < C X HØ\L¦´·�	ý /evŠÓÖòzôùNfŽ»ÃÑå•™ÈÒ ? ÿ ;ÜD:fýA	‡	¬	Ã	
ö
’ØÍãTvàE^©á   µ ¾ vÅÍ
á©³¯¯Ë0�ÿ€" 	 * 8{ß�úƒà1}œ©²Èâêu	

¨Tañ}diŒÿöø…Æ |  6îñü…Œ¤;Ê¥
ªzQûdÈö´VÍ Ž ™ Ãê9f“âTÓáëw	¾	Kƒ?UÑs©! Þ ú¬²1«³
î1éôx ¦éJg�¤¿Úö,Gc~ðp“K² ÂÐ§ XæÇæõ¾¢ãÎ4…´3Lkžüž ' 9 º Ž¶»Ü”Ñ6~+	r	¨	»	“»$´p‹ÜZ£‡µ~P¯ MoÀóÕœ	ÏþÇà	i‚o  P}Â"ÏùPX	+
9\×�ÊX«è†Ùú’.   , L Ì ï .:ˆ¯�·1OW	$cKð)7»IVwÄ'hÅ‘«¹ ¸·Åíˆ¤Ó+‡ ² Mu~¸‰è	Ó
ú9ñõ™®D' •   #šqÑíÁ3’Þˆi	¤	Õ	ú	¸
À•µk†îQÿ ŒÍÙñ�2î¾«À cádúŸ	”	<có
Œ³¾Yb Ñ Ô.žäìŽ¢É‡ 	u{aŒœŽ r K{òú:t@r	„	±	Ø	
e|ÄÐ¤ü¶ì ~ £ /gsÛ_
i°½	Ï ú “¦>­nzpÏáIeç V “ ž ° Ê FÎø8ßp	Á	£
-nX¡ßÞ€Ð ø 8R­Ã <ÖŒ¾ÝøúÄfÃÎ$ l ƒ wzþ‡}÷=dZ
§
!<iFª‹/›ÞïõfŽ?ÃƒÊ%Xl ó[t\Ë…-6¬-aØSÁn½ÂûTq¥ G–R
x
Ý
º +>g<[0`š! ]5Ê3ŠŽüH�MƒÂý	&¢Æë�w+{£^}øšèQj �§ÅÉ€á‚
 
>ÉY“À*ñ ®! œT�¯‹¸öÌÔÛ=„‹Ê	î
nt4ŽßëÁ›ý%S1ÔvÅi ô ú©í±ã	 k¢{„G7ã…¤™ B u:×Û‚[ÄK¥±Ìáé
§
ÌS‰ÒñÊÐ � ˜ Ý 5íðe¦:±Ò0y‚âèú„�ïõoÐrJ K -‡µ¶¿#b(*	§	*
Ã8³gª¸Œ·ìÆhÒØn® Ó"™pt·
¿”´ðtô˜`Ø½CX U ’ � ¯ Jfz7rÞñù	ƒ	°	À	^
d¬Ã¼yæÝ ‚ y¬ÊY
w
,;EÕRm>pÜZ ó \Šœ‰ÈƒìGŽÉ	�
%�zƒÀšv*Xz’Ó÷u™P ,t´˜ì¾Z/°')
“áf‹ïsóîônIW, T � ‘ œ ® «e›YFð�¯	X
]
v
$c
:D»àQe™uW=oíåö˜OV\ � › ¬ ­ å æ ©ª >cdƒ„VWXEWiÕÖãíîïfgŒefg!	"	#	$	6	7	M	ñ	\
“
›
#YZ[\]^9[AB\stuµÐÑÒ"nÕÖ12;<=>?HSmnäØôõz–—ÐÕÖ$ ç ~…‘ähp.%	8	N	j
‚…]v•¶Óë#XÏÞ@IToÌÙn{Ñ×& ÅÉ?ªkXj×lhÒò	}
”
œ
¬
»
>T_&Ò€G\Ç¡‚C�çT×3É  †¿;å[&	k
ù
H#�ƒ0-Å…Ø4Šf·, ] hØù!+ö%iq¿O	

M'w–²·ÍÔþ$:AkÐêAJ]ÍÚ'o|ÍÒ)f% ±°9	D	^	
…
Æ
[`Äù6^™ìY ¬ßMUp«¶J#žò 1| n è ’–Æ/ˆÛlæñ=`g†» y :ä0Y>	U	Ò	ó	•
°
gHÈ¬@a4ÊOÃ! … ,|ÆØmÙÜ3	J	b
s
~
�
©
­
¼
3?`k'7¾DèUØ«Å; íh@«•?k¦iÓy	Í…�1MLhã…î�r ¦ ÇÿÊlè•ãU—Ó]÷a¢ƒ‘&ÁÈ¡ ›¡xú
¸ÌQ’žC1R¯H5 X‡¤<CH'	•ëvµ*€(U¸»ý:=.Æg¸ ˆ BM‘\·	=
D
M
l
p$:ÝëÙm€ À¿ÍæßIc„ÃÚŠ†²‹‘ È …ôÙú8r”À
µ
¨¢V^¡<Î(p.g& w i®)÷j 	V
q
†*7Å(x—³Îÿ ;lë+FKkƒÛ}ÎÓdM  ¢&TP	B
K
„®´/1’LÕByòü8:*,±$ ^ Y?",P
Ì
Në¿iƒ¦¸ÁÜø%.Ie€�ÑBzI>#  ²ðR+@	 
¿
Ç
×
/y°ö‰\t0úG¡¼×)D{¡Â$Ÿó!} 2õ]€®(­oR	Ÿ	Æ	H
‹
da	sv8³øy´0 ‚Oç^3V`ƒIü		/	:	E	_	1
5
†
3Í7N_šíZ”àôøþ!Vu–·DKôû\³ ±ñóe	l	ÚzÅ;­Nq¬§I•2 é ñüt0‹Š	ðmq¸ç$ÉAGapÄ—r¼) H o à `“Çb4”O7g
ë
M‰˜ÜîA²ÿDò–	>¿dh”Á7p�Ûkë� —‰	j—Öß)v«´éŽVÔXè?›.§Mw f æ¾vð›¥FÄ‡8}¶×¢Û3ö‡¨Xþ' ` l%$U˜÷	EIÉÐæA— ¬Üâ5 Ú Ä;1ç	ô	
–
Ã
¼hÉáÚäQ5@ EåZª¶ê	ñ‡¥#K|PCR z í Œø/MšÆ?	V	¢	Ó	±
äu­bÁË“Ä j 	-P}¶öÙž
+4l¿æ‚¨¶5¼:¬ ã ÇnÚ4	K	\	'
t

™
ª
®
a¹ƒñéVÓ2œÆ/9 † A6R�T
e
½
Œ(T8Eº'ÙD±iGKbu<w 
r ØÝc
Ž
ß
@í�7  &©¹Ú§Ôz	PÎ†÷NWïiä,N‹ îit
z
À ¬–@»Újá
P\‚r¤é~$k…Þ†ï‘ # P Aÿ—älšÇß
˜2åûM§Ê ËÔ-s § TÙÎAS	.{ÒIÔ6öÓm„þ  Ë¼&méÁ�
VÃèè^­øb’‘žÂ [¡pÒ•ZB›˜]+£%k‚»'Ð@]·É¢ HÈ I–¢`äÎ
 «•*¨Ãú0g->  ¸Ì…	Í	"
Ó›ŸñSBI\³‰\ )7T®ÄÖ.
É
(¤Dº+ (_…²ÓÜS¯Œ œÜ¾Áy	û
_ˆ�“§Ñ¯+�°1’·w!R6¸ ¼ ý yb,‡¢ª	‘¹ÍR…t2vÞLúœý ‹ øY¥ÌßõƒÐI(	ÿ	ržw€+‹þn›£\Áêhl Z–ˆ-Y1R•Á~‘Y�_¼Y^ks>4ª/[Çò”¹  ¼=D©mv’ú-	o
é
{–²ìô°¶V¶¹Eæ.=�;VüÀi ! Ø -´ýØ˜Ð¨Á
)ÈâOœAP ‰ ½¿QÖ¼¸	m
‹r-¾`bU¡¶» �£C
þ’]¢î	E
FZ¶žOÞd	&S Aå´éN�€	Ì|	9
>
æ
Ð<�c¥`ÈÚWn�Þ# ^ây»BN
Ù
øq%+;’Úìæ¥ ) ; 7ÞŒßt	�	õ
‘àü`âdu²yø¨º/Œõ„% Áé8’S«Ÿ½	åJíô½P0ÍŸ³2¥If€£¾Ùõ+Fb}³U’Ì± ¹ L“Á5òÎJOº	&[ÄŠ�Û}¶Ä‡ªç£ Lù·ìÀç‘Ý	Ò
Èùj…Pþ‹‹�1²½a�ª É ’¥Es?q
¢
m£Wà vsÂc•©î‹Â=f‚ÃÉ$ek/_™ õËÚûL‚Á3R¢â)„hç †4µÖa9¤è¶
ÂËˆ—_ëÏq IÇ‚Éø¯	È	+Ô)y‘Ü~( « }‚�š©jDk- 	ð	W
|
%8Ñ Æ� [´Ï !<mì:Gl×yÏÔNU  \ Å°×¯*¾	
„
‡/&˜±Ì9,Lµ"(e~‰ñe{¶ x ì+g”2	=	I	T	Ñ	r
f%„Nq A£  <
C
L
BQ‰l� Ÿ¡ÿ
A
J
…06§Äxû*‚79;+-°+  �æ­'*?U_ò	Q	ž	4
G
Š
¯2c:M ÖCuzó÷ý •Có÷ú[² G e –åðˆ_Õaš“6èµ@c“oêŒ& _ k÷$#ÅT¡	
ÀJ{? Oqõ@Q×[	&
�
S¸ì¹&ÒC°»9FJ ¸ãºOq}¦„ÝÊÓ SZ »%@-zÍ
H\Òj§Âù/f��,¶  „±R®†S­	~	Ì	!
-
È
Ò^�„¦Ðu²ü& ÷Y»‚,Xl§ùÀ
è
0qz±�
^ŠX]m�Uû3áN¢Zh›[ñ“@ ä³èPxAËí	8
Ø
å
E÷;‘�Ù bÇ% µÝ"$ ¸ èø¶ÞëñÜ
	ô
äát1He¢½Øô*Ea|ŠµÃ±æô~ƒ 3`b>KpíŠ–êÂd^æ$ H|��Ä¯ÖC®½	1	<	H	S	Ç	$e€.°Ë8$9´MÖx}ˆðzµ) d ä^`™’Ÿ)5>þ3
;
@
I
‰
5bÃb9nŸ
twöú �ˆé‹öùZk% RŸöº$?·y¹ÄSZ	 	Œ
Rº ƒãçQÝW¦ø		7
ä
pÏÿWaà´YšZ°å´Ü. {Ž_˜B¸4a=JR¼ý0	;	G	2
ˆ
4ì8‰ž¯Ê7•õùÿ#€¹LÁcõY]|åO Á Â ßàáâPz�Ñ· œ�÷	F	Ü	6
‡
ã
67ÎëO`‡ˆ›œ�­®Éî6[…±²³á"WX—˜™¸$%EÀb­®¯áâãäüý9pz{Û) Ã !f èÒ½È!„õûž	`	Ý	ð
8× KšPï\†âv§&FÜêþ:q” 5 nž¬¤éÎh`�öŸ	f	™	9Æ<Qð]O3£¼EÝëƒ Ðmí ®¾"|m	vŸÛ!Ìrw¨GzÊÿr g€V!²Óò]Éü	¹ôñ
?Ø>LÖ‡®ã­!–   Ä "C+y…ÿDÎa	Þ	í&{›''¨J;à3• . 6 oŸ¥ia1ì	‹	ýâ9Ç²RSs¦¦›½ ê Ž]mnrèA%IqÏ˜ž×ìFÙîP¤F 2 4©òêýuœ ñù?jÊBHÅñ^4½Þ§  % ­Ï÷Œ g	š	:¹üÕby=ïŠì„ I p ö šÑ3ÈÙc!{¯8n	P
Û
ì
-Üó
»ÀÍÎÖ/{# R ñ a”5æp#%áh
B !EO—eÂqžÍÜè©HlìŽË ƒVî™½ïMPFwÝ ³�"”Ç?­•8sx    N á ŠCnQ•¿}å	
NŠ™ïç©“iä(•à¹	s-u‰ Š‘+²à*ÔóÊ�úX).YM@/¨äN
 "˜ä«+ð†®—  õW¹kµ^w¬µýºÉõ—	ò
"ÕÇ4ˆ¯"ºx <h�˜
×³nD
êþ
W@yš¯Ù?–=éœºê×  Î D`ç¿œ&pÅzE¤Ûî'ë(¼å‡<(+ g Å ±üñY¢¦ˆ³Ïb	9·ØYs'BNfŸ±Æ}˜ª4÷"ˆ©"4ÿ(Õ4–  >w�emòK{œ¬öÜß|œÌÇ #0j,G† 9ß	~£½Ü4Y©Ká p&º%b¸2‘	F¦f‹ÑúBo¡ÄÒæT–ŸAœÉ V¦wMüJwÊã×óø¾¼F / D Y a  éIÙ(]j™íŒ	0þ:çõO�˜Ýt6§Ó 7 = mÁU§µV	ø	þÖÔ{È\g­³ãSš¬N§¾ @ Û <E€;½iÎÝé
ÐŸG ¢A  Å<gŠB	­	
Ä
÷
äJw;á	í_€÷åRQâ Ý2r�G	ˆ	Ä	Õ
K‚“nÊÙoB&rF™Û›6¥°G ë F×þ^è	õ	
—
âsU*ØªÚï 5wþ�Îòò´Ë)CˆÆ¦S¨  © Ç€
@k$5DŽ " 3 ¶ ¿ ªÎFëæv[Æ«·ë	âI˜°1«òL_}¾ç‰ß>� ó#ªúÕ°ÌQ ´ ùC0|›³Ç@	

ð®óce�Â”÷ÅÇ { û„á‹ê~ªÉv	²
©åc~j>% 
   & + î 9O|�®ÛŽÐ0N}ÔïøW	›	Uvºý#Ö†…ù*†‘ Ð bàžÐ2�ãë�¡h	£	Ô	;bò8ízÌð ‹í q } ¢ 
.÷Ú9o	×	{hm¯ÎdµÎ% k ÷ 7Qòý[†|<Q
¦
Ü
 ,5;«¹Š.`šÝôÀe¼ÁS½÷*;W  ›~œ4·É2¨Ó�Šâ	ü	Ÿ
í
mÅê¡Èü$60|ð­˜# J — Ò!ïÚdos"¥°ÃËà¦	³7Rçùƒ©·ðÉÏ××­ ò ³ë6ëq&¿	(
€
ŠòÛómÒt* S � š ä ÄÈbUÔâìodÑ5	L	i
u
’
š
«
º
XbCFºPd˜„@Vr”êWÎÔÝ •¾:g $]	ÚL"fÃýjŸéªIÌ3�0 þ”ã/ç¥Ûâx	¯
Ì„6«í�ªÀÄÇ:Â ‡ WBLš¾GÞêu´)P‘9®9ê# Ç „ó­7SU
´
)ê¡Kh‚¥ÀÛ÷-HdŽñEy Hc=L ïðQ2‚¬d	k	¾
xˆyF»(“t²”x³! ß ï(¤ûÃN³Šf
�U¡ï·#2•Èõ@–§-6ÚjqLv ‹ÃDL~µæ	ðÈàDÏ†å–Ÿá"’4 i â 5€d
‹µ4€‚t.68v  O %s–¨™ÙÞ
à
O[ö—¿£äèúî#Mj
Š ÍoÑR¡À”Y�
AšÂçç¬ª5”$)lºÏýŸ » (·'Ò+ÛËÕ©	‡š®ð~ŒÝA[0ˆ¶Q¹[   × •,³üô¨—‘,	Q�”À}Xjå-©ÀO @]�¼áºÕ¡{	ÏY*µqN½å_¤ ( : KÝ‹’7‘ªs	¼	Ñ
�ûø_¼%O/ZžO¤Ž0ËŒ° urÁçÁ‡Èájƒ˜ f™,{
Ðÿ�
dp ïÔå¬çñ	�	
¦)B Njp#ôÖ¥É¯Òµ öXº­ÛkÊ,
ó
D]ƒ:s¥	]ØlŽ‰ð’û QãÃ#¶xY	#Qm‡‡' e~y—ÐA¶¼ôú<Q¥»öâ
Öê†Èß5„°#Y¬éyÚä“   m£lg_­þ˜	>%Ë »  $ - 3
›\ëÿ
ø@ü>iáÎ�ëx~Øî‰¥'  M Q ð ‚‰™2BØP˜åLoEà
 æN¨Æ’¬º'¸ÌÕ.,tˆ  ;�¸´m*È–	Wx™®(-¹Æ3' Í /=i° X¡%doñ8X¼AJMez›ž°ÅÚõ3—ÞËê!»!ÆÔ UèÀTv¹'Õû¥÷½[nž«@ME EÖq
‰F	Ô
J�Ü	:)öš¯ÿ¡ ¨ ÍÆ"(—Ôªæˆ=  ³ Ï NaÚÏB�Š/|é{Óîï"7ìò…)�1 – ¡ ›1Znr§Ò‰Âß¥	Ö	á	û	:¸Äég‰ ²Ç6_l™®øï#R c)ïÖ—¬ ²ý½.ê¤cÐ‘
¹
WËÙ5c‰ª“üiÚò¿ÃÁ Æ ò'£îKÂ‰c	j	ét(O¶~‡,5�’Ÿ h $ÌK4˜“´ÁZßC–«ù"# !Î‘35 Ö '?J\û�– �Ð
œ™¿^|­}�¼�/^¸¿ÊZ£ eqÓææ	¥¤È(�ÑA´c dlâ¢xfó;¤C=lƒã  2 n[•	Ld�­ô÷,ÝàÍ&w}Å2 ÌÕˆí!€!–Z©�ª?L� 0J-J—£bà	ÊÞˆ5!+ûhb Õ &1IkŸå:�£åÏ
¤¾¬
v|Ä1Ž.â Ò Ó Ô $%ÉÊË/HI‡ aÝ�  ,p  qGACNNNNNNGTC,CCAGGCCTGG,GATCCGGATC,CCWGGTACCWGG,CCANNNNNTGG,CCAGGNNNTGG,CCANNNCCTGG,CCAGGNCCTGG,GCACNNNAACGTTNNNGTGC,CACNNNGTG,CCNNNNNNNGG,AACNAACRYGTGCGTGC,GCACGCACRYGTTNGTT,GCACNAACRYGTTNGTGC,AACGCACRYGTGCGTT,GACNNNNNGTC,GAANNNNNNNTTGG,CCAANNNNNNNTTC,CACNNNNGTG,AACACNNNNGTGC,GCACNNNNGTGTT,GCANNNNNNTGC,GAACNNNNNNTCC,GGANNNNNNGTTC,CAGNNNCTG,CCAGGNNCTG,CAGNNCCTGG,CCWGGGCCC,GGGCCCWGG,CCWGGGCCCWGG,AACNNNNNNGTGCACNNNNNNGTT,GACNNNGTC,GAANNNNTTC,CCWGGTACC,GGTACCWGG,CCWGGWCCWGG,ACNNNNGTAYC,GRTACNNNNGT,CCWGGYRCCWGG,GAAGNNNNNNTAC,GTANNNNNNCTTC,AACGGCNNNGTGC,GCACNNNGCCGTT,GCACGGCNNNGTT,AACNNNGCCGTGC,CGANNNNNNTGC,GCANNNNNNTCG,CGATCNNNNTGC,GCANNNNGATCG,TGANNNNNNTCA,TGATCNNNNTCA,TGANNNNGATCA,TGATCNNGATCA,AACCTGCNNGTGC,GCACNNGCAGGTT,GCACCTGCNNGTT,AACNNGCAGGTGC,GCCNNNNNGGC,AACNNNNNNGTGCMC,GKGCACNNNNNNGTT,CCWGGNCCWGG,AACTGGGNNGTGC,GCACNNCCCAGTT,GCACTGGGNNGTT,AACNNCCCAGTGC,GACNNNNGTC,GAGNNNNNCTC,CCWGGTCTC,GAGACCWGG,GATNNNNATC,GATCNNNATC,GATNNNGATC,GATCNNGATC,CCWGGCGCCWGG,ACNNNNNCTCC,GGAGNNNNNGT,AACNNNNNNGTGCAG,CTGCACNNNNNNGTT,GATCATGATC,CCWGGNNCCWGG,AACTGGNNNGTGC,GCACNNNCCAGTT,GCACTGGNNNGTT,AACNNNCCAGTGC,AACNAACCGGTGCGTGC,GCACGCACCGGTTNGTT,GCACNAACCGGTTNGTGC,AACGCACCGGTGCGTT,GCANNNNNTGC,GCACNNNNNNGTTCGAACNNNNNNGTGC,CCTNNNNNAGG,GCNNNNNNNGC,CCANNNNNNTGG,CCAGGNNCCTGG,CCTGGCCAGG,CAANNNNNGTGG,CCACNNNNNTTG,TTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAA,GCACNNNNNNGTTTAAACNNNNNNGTGC,CCAGGNCCY,RGGNCCTGG,CCWGGGNCCTGG,CCAGGNCCCWGG,AAGNNNNNCTT,GAYNNNNNVTC,GABNNNNNRTC,GAYNNNNNRTC,GATCNNNNVTC,GABNNNNGATC,GAYNNNNGATC,GATCNNNNRTC,GATCNNNGATC,GTYAACNNNNNNGTGC,GCACNNNNNNGTTRAC,GCACNNNNNNGTTAACNNNNNNGTGC,GATCNGATC,TAACTATAACGGTCCTAAGGTAGCGA,TCGCTACCTTAGGACCGTTATAGTTA,CTCTCTTAAGGTAGC,GCTACCTTAAGAGAG,TAGGGATAACAGGGTAAT,ATTACCCTGTTATCCCTA,GTTAACNNNNNNGTGC,GCACNNNNNNGTTAAC,AACNAACGCGTGCGTGC,GCACGCACGCGTTNGTT,GCACNAACGCGTTNGTGC,AACGCACGCGTGCGTT,TCCAACNNNNNNGTGC,GCACNNNNNNGTTGGA,CAYNNNNRTG,AACAYNNNNGTGC,GCACNNNNRTGTT,GTTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAAC,CCWGGCGCC,GGCGCCWGG,CCWGGNNCC,GGNNCCWGG,GATCGCGATC,AACNAACATGTGCGTGC,GCACGCACATGTTNGTT,GCACNAACATGTTNGTGC,AACGCACATGTGCGTT,TGGCAAACAGCTATTATGGGTATTATGGGT,ACCCATAATACCCATAATAGCTGTTTGCCA,ATCTATGTCGGGTGCGGAGAAAGAGGTAATGAAATGG,CCATTTCATTACCTCTTTCTCCGCACCCGACATAGAT,AACNNGCACGTGCNNGTT,GAACNNNNNCTC,GAGNNNNNGTTC,CCAGGWCCY,RGGWCCTGG,CCWGGGWCCTGG,CCAGGWCCCWGG,CCAGGWCCTGG,TTATAACNNNNNNGTGC,GCACNNNNNNGTTATAA,GCACNNNNNNGTTATAACNNNNNNGTGC,GAACNNNNNNTAC,GTANNNNNNGTTC,GGCCNNNNNGGCC,AACNNACTAGTGC,GCACTAGTNNGTT,AACTAGTNNGTGC,GCACNNACTAGTT,AACNAACTAGTGCGTGC,GCACGCACTAGTTNGTT,GCACNAACTAGTTNGTGC,AACGCACTAGTGCGTT,AACNNNAACGTGCNNGTGC,GCACNNGCACGTTNNNGTT,GCACCCANNNGTT,AACNNNTGGGTGC,TTAACNNNNNNGTGC,GCACNNNNNNGTTAA,CACNNNNNNTCC,GGANNNNNNGTG,CACNNNNGATCC,GGATCNNNNGTG,GATCTAGATC,CCANNNNNNNNNTGG,CCAGGCCT,AGGCCTGG,CCTCGAGG,GATCCGGA,TCCGGATC,GGCGCGCC,GCGATCGC,CCWGGWCC,GGWCCWGG,GATCGATC,GATCATGA,TCATGATC,GCGGCCGC,CCTGGCCR,YGGCCAGG,CCWGGNCC,GGNCCWGG,GGCCGGCC,RTGCGCAY,GATCNNGA,TCNNGATC,CGCGCGCG,CCTGGCCA,TGGCCAGG,CGCCGGCG,GTTTAAAC,GATCGCGA,TCGCGATC,TTAATTAA,VCTCGAGB,CCTGCAGG,CRCCGGYG,CGTCGACG,ATTTAAAT,GCCCGGGC,GATCTAGA,TCTAGATC,CACCTGC,GCAGGTG,CCTNAGG,GATCGAT,ATCGATC,CCTCAGC,GCTGAGG,GCTNAGC,CCTNAGC,GCTNAGG,GCTCTTC,GAAGAGC,GGTNACC,CGGWCCG,ACCWGGT,RGGNCCY,CCTGGAG,CTCCAGG,GGTGATC,GATCACC,GATCNGA,TCNGATC,GGGWCCC,GAAGATC,GATCTTC,CCCWGGG,TCCNGGA,TCCWGGA,RGGWCCY,TTATAA,AGGCCT,GACGTC,GTMKAC,TCCGGA,TGCGCA,ACCTGC,GCAGGT,GGTACC,AGTACT,GGYRCC,CCGCTC,GAGCGG,AACGTT,YGGCCR,RAATTY,CTGAAG,CTTCAG,CACGTG,GRCGYC,AGCGCT,CTTAAG,ACRYGT,ACCGGT,ACTAGT,CACGTC,GACGTG,GWGCWC,GTGCAC,CYCGRG,GGGCCC,ATTAAT,CCTAGG,TTCGAA,GCTAGC,GKGCMC,TGGCCA,GGATCC,GRGCYC,ATCGAT,CACGAG,CTCGTG,GGCGCC,GAAGAC,GTCTTC,GCATGC,GTATCC,GGATAC,TGATCA,ACTGGG,CCCAGT,CTRYAG,RGCGCY,AGATCT,GGNNCC,CTGGAG,CTCCAG,CTTGAG,CTCAAG,CGATCG,GGTCTC,GAGACC,YACGTR,CCNNGG,GAATGC,GCATTC,WCCGGW,GCAATG,CATTGC,RCCGGY,GCGCGC,GAGGAG,CTCCTC,CGGCCG,CCCAGC,GCTGGG,GTGCAG,CTGCAC,CGRYCG,CGTACG,CGTCTC,GAGACG,CCATGG,TCGCGA,GDGCHC,TGTACA,TCATGA,ACATGT,GTATAC,CCWWGG,CTCTTC,GAAGAG,GCNNGC,CCRYGG,GTTAAC,RCATGY,TACGTA,RGATCY,GCGATG,CATCGC,GCAGTG,CACTGC,CCCGGG,CCGCGG,TTTAAA,GGCGGA,TCCGCC,GAGCTC,GATATC,CTGRAG,CTYCAG,CAGCAG,CTGCTG,GAATTC,ATGCAT,CATATG,GTYRAC,AAGCTT,GTNNAC,TCNNGA,CAATTG,ACGCGT,TCCRAC,GTYGGA,GCCGGC,CMGCKG,GCCGAG,CTCGGC,CTCGAG,CTGCAG,CAGCTG,GTCGAC,CTYRAG,AATATT,GATCGA,TCGATC,GACCGA,CACCCA,TCGGTC,TGGGTG,WGTACW,TARCCA,TGGYTA,TCTAGA,GGATC,GATCC,CCWGG,GTCTC,GAGAC,GCWGC,GGNCC,CCSGG,GGTGA,TCACC,GGWCC,GCAGC,GCTGC,CCATC,GATGG,ACGGC,GCCGT,GCNGC,CCNGG,GCATC,GATGC,ACTGG,CCAGT,GGATG,CATCC,CTCAG,CTGAG,GGGAC,GTCCC,ACNGT,CTNAG,CAGTG,CACTG,GACGC,GCGTC,CCCGC,GCGGG,GANTC,CGWCG,TCNGA,CCTTC,GAAGG,GTNAC,GAAGA,TCTTC,GAGTC,GACTC,GTSAC,GAWTC,GCSGC,CASTG,ATGAA,TTCAT,ACGGA,TCCGT,CGCG,CCGC,GCGG,GTAC,AGCT,GCGC,CTAG,GATC,GGCC,CCGG,CATG,RGCY,YATR,ACGT,TGCA,AATT,CCTC,GAGG,TTAA,ASST,TCGA                                                                                                                                                                                                                                                                                                                                                         #                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
                                                                                  
                                                                  	                                                                                                                                    
                                                                                                                                                                         	                                	                                  
   
   	                                                                           %         "      (            X   ^      %   %         $   S                                                                                                                                                                    #                                                                                                                                                                                                                                                                                                  
                                
                        	                                                  
                                                         	            	            
 
 	                         %   "  (    X ^  % %   $ S   qA  r;  rU  rƒ  va  zq  €!ì ©Ë~– ¨ NeŸåœËt¥(_�ò ¯.Áþœª#¯!R¯®«V5´Ø ‹lui	Q�•FÂ¯Ì¥  C µ ñu©«Õði	‡	ÀzÏµ»ÄÅÎ«ÓQ¦¯ÈíöŒ�	öY…"ª„þHpÃ±þj ±þ±pÃ¾ûšª#6¡ ¸hü9`½„°î€¼±7±Ãš¹?B¼ÍÊÕom— ó¸e®;—¾¦p»Àliªf|f|þ5Ã�Öíe¼ßt	]ÉÐáÏWh3Ðüþû�_î)A JÑäY‡ø	¬¾8	C	5]ëX«ÞTo•Àj­Ëð†¨®þ† 8­R¤QÀIžóÌ�²¶œ¢ÑÀžóÌ²Î��?®³y´OÀžÇÅó Ì²JÕ5G¶Ñm$p—3›þY¹WNÊ
½é
–ì°ï0à	�Nô¡
¦OË záéSþ¥¤ Ë Ï-V)w6BWÕºHh3Ðüþû�»_¹Xež°Å—!Ôölð orˆ	oü
”èFÿ~ð†"&Ö	™CO¬à(ò b�3?ZG„x“Tç&ö¼9ïF»(SÔ
öJ›õÞË¬5¶Z‡T¼/ ×rˆ	o¬OÀIž5ÇÅóG Ì�²J¶œ¢Ñ¶VF³8† 8O –	? • º êqÞì�	¤	¨	
ÜîåíˆŒ•öŽ«CO(ò3† 8éhtt…6ÕÒ¥’EŠ·Œ¨öMŠ�?ò{ŽBÕÎ `œë¶Ñ³‘•Àj¹X­ež°Å—!ËÔïù’«‘ÖíM?)
‹À¨ž{²Ã'ó©ŸÌ²ÖíMe?oõW¹VYFå	9·³{?˜BÅœ¼ê8×(—›Ÿ�­Dü4(©¬ÚÏ|¦	"ðò…Ï­~¥Î�OË¦	­Öíð öoÎl�%O	ÔAponA˜¡). iìÌá¶¶
œÁ	_Í+—htÕýÒ¿½uE†7|ÖÚWý¡ 'Ö	™gl®­} c¸ZCý
•<éFÿ' 9 Ü î6¤Êr	»	»$Q£È~¯-|�k†’	†¨ô2›¹¥Zn�žª?@LÝÎt~®;q™nQ¿™©“(¹�k¨ô2 î¤ÊQÈ' 9 Ü6r	»	»$£~¯'£Â‰¶,5w·ËGlU÷	¬â' 9 < ² MÜ î6‰¤è¦´Êr	»	ý»$QÓz£ñfÈ~™¯¡ '¹Ö	™g¥l®­} Znc�žª?@L¸ZÞ ú²î1ô¦pÌbÂÙ±&ÚÔ†ï›1§Ò‰á	û	Äé Ç#ï—µ	Øï¤Ã¡2õ§™2ØºÕ.ô�À¥¢` § }¶¹˜z	ž
lÎ5Óæ—Ü5¬™2Øô�º�Õ.À4É2�ü	Åê| %¨OöîMŠì .™ãt©¯Ëí!�·�	 eŠùÃÑå•È" m ùþ°Æ
jkåÙðF<_É,¦H£ºë è	õ	âsúÕØª°ÚQö D¥+²p{óEP
Û
Û-Üóâ
»À(¨Nl¢f=yÝ‚	«Âxë*ž¹>×“ÃÏÐ	ä	Çã”ßxlY k^¬ý—	ºù°jF£" þÆ
É,×Ïä	Çã”ßm kåÙð<_¦Hº< ² M‰è¦´ýÓzñf™ %4É2�¨ü	OÅêöîM|Š‡€»=.Æ¸ívŸ!rwÿIÉÅ'å‡<´ ùC0|›³Ç@	

ð®óce�Â”÷ÅÇ ³ Ï NaÚÏB�Š/|é{Óîï"7ìò…)�< C X HØ\L¦´·�	ý /evŠÓÖòzôùNfŽ»ÃÑå•™ÈÒâ%
G[p·|Ñ+8EK -‡µ¶¿#b(*	§	*
Ã8³gª¸Œ·ìÆhÒØn®	 * 8{ß�úƒà1}œ©²Èâêu	

¨Tañ}diŒÿöø…ÆurÁçÁ‡Èájƒ˜½iuÞ3Esu†ª‰	ê
7L|—Öí±ÚþpÓCWFo¾Ãç>šÀWýœ¦” Ÿ ± c-}ˆ‡	“	ù	†	›­¿UèÀTv¹'Õû¥÷½[nž«@ME‡ WBLš¾GÞêu´)P‘9®9ê8 K ” Ÿ ± Ë -‡µºÓ"cn™¶!-Vpt}¿#bˆ(6‡	*	q	“	§	ù	*
·
¿’ºÎH†”´Ã8³goª¸YŒ¢·Éðt´ô	˜`ØìW›­ÆßOh�½ÒØCXn®¿‡ Ç „AWŸ¡£óBLš ­¾ 7GSÿ
<
A
C
J
L
U
´
…Þê)06u§´)P‘Ä9BêQ¡®9êKh‚¥ÀÛ÷-HdxŽñû*Ey‚‰ 79;+-Hcl�°=LEåZª¶ê	ñ‡¥#K|PCRÁé8’S«Ÿ½	åJíô½P0ÍŸ³2¥If€£¾Ùõ+Fb}³U’Ì±±°9	D	^	
…
Æ
[`Äù6^™ìY ¬ßMUp«¶J#žò 1| 2 n[•	Ld�­ô÷,ÝàÍ&w}Å2ù =Í,Ïo HÞûëÏH|��Ä¯ÖC®½	1	<	H	S	Ç	$e€.°Ë8$9´MÖx}ˆðzµK ú -[‡“¦µ>¡¶EpÒ¿å#bZ•(Zª¶*	§	ê	*
B›ñ˜­]Ã8n³+gz£‡ª¸pŒ·Ïá%I¥#kK‚»'e|Ðçì@PÆ]h·CRÉÒØn¢®ê Ž]mnrèA%IqÏ˜ž×ìFÙîP¤F   -<AlignableSequences trimStringency="Medium"/>  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  %“<?xml version="1.0"?><Features nextValidID="17"><Feature recentID="0" name="vermilion" directionality="2" translationMW="44421.98" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="2780-2897" color="#993366" type="standard" translated="1"/><Segment range="2898-2973" color="noColor" type="gap"/><Segment range="2974-3067" color="#993366" type="standard" translated="1"/><Segment range="3068-3158" color="noColor" type="gap"/><Segment range="3159-3765" color="#993366" type="standard" translated="1"/><Segment range="3766-3819" color="noColor" type="gap"/><Segment range="3820-3953" color="#993366" type="standard" translated="1"/><Segment range="3954-4013" color="noColor" type="gap"/><Segment range="4014-4174" color="#993366" type="standard" translated="1"/><Segment range="4175-4247" color="noColor" type="gap"/><Segment range="4248-4273" color="#993366" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;selectable marker, required to synthesize the brown eye pigment in &lt;i&gt;Drosophila&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;tryptophan oxygenase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MSCPYAGNG,,NDHDDSAVPLTTEVGKIYGEYLMLDKLLDAQCMLSEEDKRPVHDEHLFIITHQ,,AYELWFKQIIFEFDSIRDMLDAEVIDETKTLEIVKRLNRVVLILK,,LLVDQVPILETMTPLDFMDFRKYLAPASGFQSLQFRLIENKLGVLTEQRVRYNQKYSDVFSDEEARNSIRNSEKDPSLLELVQRWLERTPGLEESGFNFWAKFQESVDRFLEAQVQSAMEEPVEKAKNYRLMDIEKRREVYRSIFDPAVHDALVRRGDRRFSHRALQGAIMITFYRDEPRFSQPHQLLTLLMDIDSLITKWR,,YNHVIMVQRMIGSQQLGTGGSSGYQYLRSTLS,,DRYKVFLDLFNLSTFLIPREAIPPLDETIRKKLINKSV*"/></Q></Feature><Feature recentID="1" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="1746" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="955-1746" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="1747-1815" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MSIQHFRVALIPFFAAFCLPVFA,HPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRIDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPVAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW*"/></Q></Feature><Feature recentID="2" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="196-784" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="f1 ori" directionality="1" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1947-2403" color="#ffff00" type="standard"/><Q name="direction"><V text="RIGHT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;f1 bacteriophage origin of replication; arrow indicates direction of (+) strand synthesis&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="dU6-3 promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5298-5718" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;RNA polymerase III promoter for &lt;i&gt;Drosophila&lt;/i&gt; U6-3 snRNA (&lt;a href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/25002478&quot; title=&quot;http://www.ncbi.nlm.nih.gov/pubmed/25002478&quot;&gt;Port et al., 2014&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="gypsy insulator" type="protein_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4899-5284" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;Su(Hw), CP190, and&#10;Mod(mdg4)67.2&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;chromatin insulator from &lt;i&gt;Drosophila&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1816-1920" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="gRNA scaffold" directionality="1" type="misc_RNA" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5824-5899" color="#00ccff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;guide RNA scaffold for the &lt;i&gt;Streptococcus pyogenes&lt;/i&gt; CRISPR/Cas9 system&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="gRNA scaffold" directionality="1" type="misc_RNA" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5986-6061" color="#00ccff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;guide RNA scaffold for the &lt;i&gt;Streptococcus pyogenes&lt;/i&gt; CRISPR/Cas9 system&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="attB" type="protein_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4588-4657" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;phage&amp;nbsp;Ï†C31 integrase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;attB site for the Ï†C31 integrase (&lt;a href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/10801973&quot; title=&quot;http://www.ncbi.nlm.nih.gov/pubmed/10801973&quot;&gt;Groth et al., 2000&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment name="-10" range="6459-6465" color="#ffffff" type="standard"/><Segment range="6466-6483" color="#ffffff" type="standard"/><Segment name="-35" range="6484-6489" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6504-6525" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="T7 promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2570-2588" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for bacteriophage T7 RNA polymerase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="T3 promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6372-6390" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for bacteriophage T3 RNA polymerase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="M13 fwd" directionality="1" type="primer_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2544-2560" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="M13 rev" directionality="2" type="primer_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6411-6427" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6435-6451" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  ’<Notes>
<UUID>55ecc14a-1492-4edd-abd1-7389441c24ac</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<CustomMapLabel>pCFD5</CustomMapLabel>
<UseCustomMapLabel>1</UseCustomMapLabel>
<Created UTC="2:58:42">2019.4.30</Created>
<LastModified UTC="23:55:10">2025.8.26</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  Y     K         
?????                                                                                                       ÿ d      HO  d               E              ÿÿÿÿYô? P                                                                                                                                                              3<?xml version="1.0"?><EnzymeVisibilities vals=""/>
   )<?xml version="1.0"?><CustomEnzymeSets/>
